However, our endocannabinoid system function is also closely interlinked with the endocrine system. The use of cannabinoids can influence major hormones such as cortisol, insulin, and melatonin, which is why cannabis can be used to naturally treat hormone disorders. Symptoms of hormonal disorders or imbalances vary, though these can include weight gain, poor sleep, fatigue, depression, anxiety, and loss of libido among others.