Retail store owners earn on average between $250,000 dollars and $450,000 a year, but a small percentage of these businesses makes up a million dollars in a year. The average cannabis retail store produces around $2 million yearly in sales with a 12% margin in profit.  The current federal 280E tax code makes profits shrink quickly in the cannabis world. Cannabis businesses can’t take write-offs for their business, since cannabis is currently a Schedule 1 drug on the CSA.